Nathalie Spassky

Static2Dynamic reconstructs unseen biological dynamics from static images, enabling simulation of cellular and developmental processes not directly observable.

This study shows that inhibiting EJC assembly with EJC-i disrupts mRNA localization and neural stem cell ciliogenesis by affecting multiple post-transcriptional processes.

This study shows that tRNA thiolation defects in humans cause proteostasis and tissue homeostasis issues, but mice with similar defects develop normally.

The paper shows that GPR161 at the primary cilium senses mechanical stimuli to drive cyclic saltatory neuronal migration through cAMP/PKA signaling and NDE1 phosphorylation.

The paper investigates the role of P73+ Cajal-Retzius cells and Reelin in cortical morphogenesis, finding that CRs-derived Reelin is essential for radial migration arrest, while CRs also have Reelin-independent functions in hippocampal progenitor proliferation and vessel remodelling.

Cyclin O is necessary for multiciliated cells to enter their differentiation cell cycle variant and allows the massive amplification of centrioles, which serve as basal bodies for cilia nucleation.

The paper identifies a new cell cycle variant in multiciliated cells that enables centriole amplification without DNA replication or mitosis.

This study shows the MCC cell cycle variant accelerates centriole biogenesis by overlapping two cycles to produce multiple mature centrioles without cell division.

The paper shows that choroid plexus cilia undergo axoneme resorption through microtubule destabilization, controlled by polyglutamylation and spastin, and is conserved in human samples.

This study shows that actin-based nuclear deformations are essential for multiciliated ependymal cell differentiation in mice.

The paper identifies a gene regulatory network involved in multiciliation that is repurposed in the fate specification of Cajal-Retzius neurons, leading to distinct cellular outcomes.