Julia Thorn‐Seshold

The delivery of nano-formulated drugs to solid tumours is selectively increased by co-application of the vascular disrupting agent CA4P

This paper shows that co-administering vascular disrupting agents with nanoparticle drugs increases tumoral uptake without increasing systemic exposure.

RIG-I-like receptor-dependent type I Interferon regulates antigen dose and activation in yellow fever vaccine 17D-infected antigen presenting cells

This study shows that type I interferon, induced by RIG-I-like receptors, restricts YF17D replication in antigen-presenting cells, thereby limiting antigen presentation to T cells.

Logic-gating the HaloTag system with Conditional-Halo-ligator 'CHalo' reagents

The paper introduces CHalo reagents that conditionally ligate to HaloTag proteins, enabling light- or enzyme-triggered labeling, protein recruitment control, and enzyme activity recording.

Cellularly-Retained Fluorogenic Probes for Sensitive Cell-Resolved Bioactivity Imaging

This paper develops a fluorogenic probe scaffold that retains fluorescent products within cells to improve imaging sensitivity and resolution for quantifying low-turnover biological processes.

Imaging membrane damage in ferroptosis and necrosis by wash-free fluorogenic chemical probes

The paper develops fluorogenic chemical probes that detect membrane damage without washing steps, enabling in vivo imaging of cell death mechanisms like ferroptosis and necrosis.