Judith Klein‐Seetharaman

Developmental Convergence Across Diverse Genetic Architectures in Childhood Apraxia of Speech

The paper identifies multiple genetic variants associated with childhood apraxia of speech through whole-exome sequencing and functional analysis, proposing four novel candidate genes.

GO-Term Enrichment of Proteome-Scale Docking Profiles as a Biological Search-Space Reduction Layer for Protein Target Discovery

GO enrichment of proteome-scale docking profiles shrinks the candidate target list: a held-out GO gate kept 11.32% of known targets in 1.26% of candidates; additive reranking was mixed.

Decoding the Functional Interactome of Non-Model Organisms with PHILHARMONIC

PHILHARMONIC infers protein interaction networks and functional organization in non-model organisms using deep learning and spectral clustering, validated in Drosophila and coral symbionts.

PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance

The paper identifies PRDX6 as an alternative pathway for selenocysteine metabolism that contributes to ferroptosis resistance in cancer cells.

Transfer of Knowledge from Model Organisms to Evolutionarily Distant Non-Model Organisms: The Coral Pocillopora damicornis Membrane Signaling Receptome

The paper develops a method to identify homologous membrane receptors in non-model corals by combining remote homology detection and functional analysis, mapping over 1000 human receptors to coral receptors.