Author

Zehua Guo

Shanghai Jiao Tong UniversityORCID 0000-0002-8601-7158Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein design· 1

Frequent Co-Authors

Guang HeiD· 2 shared Mingxuan ZhangiD· 2 shared Xianbin SuiD· 2 shared Yi Y. ShiiD· 2 shared Guoying Wu· 1 shared Hui ShiiD· 1 shared Jialu Hou· 1 shared Jiayi WangiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioinformatics

Guang HeORCID

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3 papers

Recent·Most cited

Exploring DNA methylation profiles in the pathogenesis of human osteoporosis via whole-genome bisulfite sequencing

Yinyin Zhang, Guoying Wu, Jialu Hou, Yeling Zhong, Yukai Zhang, Shishuo Xiong, Zehua Guo, Ying Li

The paper identifies differential DNA methylation patterns in osteoporosis patients compared to controls, highlighting six genes potentially involved in osteoporosis pathogenesis.

PLoS ONE · Jul 16, 2026Peer-reviewedGenetics

3D Genome Contributes to Protein-Protein Interactome

Yi Y. Shi, Song Cao, Mingxuan Zhang, Xianbin Su, Zehua Guo, Jiayi Wang, Tingting Liu, Hui Shi, Guang He

The paper investigates how 3D genome structure influences protein-protein interactions and shows that gene proximity in 3D space correlates with interaction likelihood.

bioRxiv · Nov 30, 2020 · PreprintBioinformatics

A Novel Neoantigen Discovery Approach based on Chromatin High Order Conformation

Yi Y. Shi, Mingxuan Zhang, Luming Meng, Xianbin Su, Xueying Shang, Zehua Guo, Qingjiao Li, Mengna Lin, Xin Zou, Qing Luo, Yaoliang Yu, Yanting Wu, Lin‐Tai Da, Tom Weidong Cai, Guang He, Ze‐Guang Han

This paper identifies that immuno-positive neoantigens cluster in 3D genome regions and are enriched in active chromosomal compartments, suggesting 3D genome information can improve neoantigen prioritization.

BMC Medical Genomics · Aug 1, 2020Peer-reviewedBioinformatics