Gary R. Whittaker

This study evaluates antiviral treatments for HPAI in felines, finding baloxavir most effective in vitro, while oseltamivir and others show limited efficacy.

This study reports a serosurvey of cats in New York City during the early pandemic, finding 16% seropositive for SARS-CoV-2 with higher prevalence in fall 2020 and evidence of human-cat transmission.

The paper identifies a deletion in domain 0 of the spike gene in highly pathogenic feline coronavirus type 2 from U.S. cats, suggesting it as a biomarker for pathogenicity.

This study shows that a deletion in the NSP1 protein of SARS-CoV-2 variants reduces virulence by impairing host translation shutoff, suggesting NSP1 as a target for antiviral strategies.

This study identifies the L260F mutation in NSP6 as enhancing RNA replication and pathogenesis in recent SARS-CoV-2 variants, independent of Spike function.

This study reports an outbreak of canine coronavirus type 2 in snow leopards, suggesting felids may act as mixing vessels for alphacoronaviruses.

This study identifies molecular mechanisms of FCoV-23 pathogenicity, including receptor usage and biotype switching, and identifies a cross-reactive antibody for therapeutic development.

The paper shows that inhibiting glutaminase enzymes blocks coronavirus replication in mammalian cells, suggesting these inhibitors as potential anti-viral drugs.

The paper tracks intra-host variation in the spike S1/S2 region of FCoV-1 in a cat over six years, showing distinct variants in different tissues and shedding patterns.

The paper constructs a 3D structural interactome of SARS-CoV-2-human protein interactions, analyzing evolutionary divergence, population variation, and drug impacts.

The paper performs phylogenetic analysis of Alphacoronavirus 1 species using the spike gene to identify two distinct clades and proposes a new species classification.