Cancer BiologybioRxivPreprint
CTPS1 inhibition synergizes with replication stress signaling inhibition in MYC-amplified Group 3 medulloblastoma
Matthew R. Hathaway, Katherine E. Gadek, H. L. Jagana…·Myron K. Evans
This study identifies CTPS1 as a vulnerability in MYC-driven medulloblastoma and shows that combining CTPS1 and CHK1 inhibition synergistically reduces tumor growth in vivo.
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