Author

H. L. Jagana

Seattle Children's Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Ashmitha RajendraniD· 1 shared Aya MiyakiiD· 1 shared Barbara Stauch SlusheriD· 1 shared Isabella Terrones· 1 shared J. M. Hemenway· 1 shared Katherine E. GadekiD· 1 shared Leonel Elena-SancheziD· 1 shared Matthew R. HathawayiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Ashmitha RajendranORCID

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1 paper

Recent·Most cited

CTPS1 inhibition synergizes with replication stress signaling inhibition in MYC-amplified Group 3 medulloblastoma

Matthew R. Hathaway, Katherine E. Gadek, H. L. Jagana, Isabella Terrones, J. M. Hemenway, Aya Miyaki, Ashmitha Rajendran, Michael Meechan, Leonel Elena-Sanchez, Nicholas Alexander Vitanza, Barbara Stauch Slusher, Siobhan S. Pattwell, Myron K. Evans

This study identifies CTPS1 as a vulnerability in MYC-driven medulloblastoma and shows that combining CTPS1 and CHK1 inhibition synergistically reduces tumor growth in vivo.

bioRxiv · Jun 3, 2024 · PreprintCancer Biology