Evolutionary persistence of DNA methylation for millions of years after ancient loss of a de novo methyltransferase
Sandra Catania, Phillip A. Dumesic, Harold Pimentel, Ammar Nasif, Caitlin I. Stoddard, Jordan E. Burke, Jolene K. Diedrich, Sophie L. Cooke, Terrance Shea, Elizabeth Gienger, Robert E. Lintner, John R. Yates, Petra Hájková, Geeta J. Narlikar, Christina A. Cuomo, , Hiten D. Madhani
The paper shows that DNA methylation persists in Cryptococcus neoformans despite the loss of a de novo methyltransferase, with methylation patterns maintained through replication and natural selection.
Cell · Jan 1, 2020Peer-reviewedMolecular Biology