Sandra Catania

This study identifies transient heterochromatin islands in Cryptococcus neoformans that contribute to fluconazole heteroresistance, distinct from aneuploidy.

This paper identifies and characterizes the titanide morphotype of Cryptococcus neoformans, showing its distinct morphology, resistance to stress, and role in pathogenesis.

The paper reveals the structural mechanism of ATP-dependent DNA methylation by DNMT5, showing how hemimethylated DNA activates the SNF2 ATPase domain and remodels the catalytic pocket for specificity.

The paper shows that ATP hydrolysis by the SNF2 domain of Dnmt5 is coupled to DNA methylation, enhancing substrate specificity through base-flipping mechanisms.

The paper shows that DNA methylation persists in Cryptococcus neoformans despite the loss of a de novo methyltransferase, with methylation patterns maintained through replication and natural selection.