Author

Yujie Zhang

Science for Life LaboratoryORCID 0000-0002-4926-028XUnclaimed ORCID profile · follow to get notified of new preprints

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Yujie Zhang4 papers · Gladstone Institutes

Biology Disciplines

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Genomics· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Vicent PelechanoiD· 3 shared Bianca P. HennigiD· 1 shared Christophe D. ChabbertiD· 1 shared Evangelos Theodorakis· 1 shared Ilaria PiazzaiD· 1 shared Jingwen WangiD· 1 shared Julien GagneuriD· 1 shared Lars Michael SteinmetziD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenomics

Vicent PelechanoORCID

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3 papers

Recent·Most cited

Cellular energy regulates mRNA translation and degradation in a codon-specific manner

Pedro Tomaz da Silva, Yujie Zhang, Evangelos Theodorakis, Laura D. Martens, Vicente A. Yépez, Vicent Pelechano, Julien Gagneur

The paper shows codon optimality affects mRNA stability across human tissues, with energy metabolism and age modulating this effect.

bioRxiv · Apr 6, 2023 · PreprintSystems Biology

High-throughput 5'P sequencing enables the study of degradation-associated ribosome stalls.

Yujie Zhang, Vicent Pelechano

The paper introduces HT-5Pseq, a method to study degradation-associated ribosome stalls, finding that Arginine before stop codons is enriched in these stalls, while TAA stop codons are more common in stable mRNAs.

Cell Reports Methods · Apr 2, 2021Peer-reviewedGenomics

Chromatin-sensitive cryptic promoters encode alternative protein isoforms in yeast.

Wei Wu, Bianca P. Hennig, Jingwen Wang, Yujie Zhang, Ilaria Piazza, Yerma Pareja Sanchez, Christophe D. Chabbert, Sophie H. Adjalley, Lars Michael Steinmetz, Vicent Pelechano

The paper identifies chromatin-sensitive cryptic promoters in yeast that generate alternative protein isoforms through truncated mRNAs.

Genome Research · Dec 1, 2019Peer-reviewedGenomics