This study identifies 210 genetic loci associated with the PR interval through multi-ancestry GWAS, highlighting their role in cardiac conduction and cardiovascular disease.

bioRxiv · Jul 30, 2019 · PreprintGenetics

KCND3 is a novel susceptibility locus for early repolarization

Alexander Teumer, Teresa Trenkwalder, Thorsten Kessler, Yalda Jamshidi, Marten E. van den Berg, Bernhard M. Kaess, Christopher P. Nelson, Rachel Bastiaenen, Marzia De Bortoli, Alessandra Rossini, Isabel Deisenhofer, Klaus J. Stark, Solmaz Assa, Peter S. Braund, Claudia Cabrera, , Wibke Reinhard

This study identifies a genome-wide significant association between a variant in the KCND3 gene and early repolarization pattern on ECG, suggesting a genetic basis for this trait.

bioRxiv · Jun 18, 2019 · PreprintGenetics

Discovering patterns of pleiotropy in genome-wide association studies

Jianan Zhana, CHARGE ECG Working Group, Jessica van Setten, Jennifer A. Brody, Brenton R. Swenson, Anne M. Butler, Harry Campbell, Fabiola Del Greco M, Daniel S. Evans, Quince Gibson, Daniel Fannar Gudbjartsson, Kathleen F. Kerr, Bouwe P. Krijthe, Leo‐Pekka Lyytikäinen, Christian Müller, , Steven Ron Cummings

This paper introduces SAPPHO methods to detect pleiotropy in GWAS by modeling shared patterns of genetic associations, finding 16 additional and 124 novel loci in meta-analysis.

bioRxiv · Feb 28, 2018 · PreprintGenetics

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

Jessica van Setten, Jennifer A. Brody, Yalda Jamshidi, Brenton R. Swenson, Anne M. Butler, Harry Campbell, M. Fabiola Del Greco, Daniel S. Evans, Quince Gibson, Daniel Fannar Gudbjartsson, Kathleen F. Kerr, Bouwe P. Krijthe, Leo‐Pekka Lyytikäinen, Christian Müller, Martina Müller‐Nurasyid, , Paolo Gasparini

This study identifies 47 novel genetic loci associated with PR interval through genome-wide association meta-analysis across multiple populations.

bioRxiv · Jan 17, 2018 · PreprintGenetics