Thorsten Kessler

This study develops a monoclonal antibody against ADAMTS-7 that reduces atherosclerosis in mice without affecting lipid levels or causing toxicity.

This study investigates how ZC3HC1 deficiency affects vascular smooth muscle cell behavior and neointima formation using in vitro and in vivo models.

This study shows cigarette smoke increases vascular ADAMTS7 expression through CCL17-CCR4 signaling, linking smoking to atherosclerosis via a novel gene-environment interaction.

The paper introduces a statistical method to assess the impact of DNA variations on transcription factor binding, showing improved speed and accuracy over existing approaches.

This study identifies ADAMTS-7 as a risk factor for atherosclerosis by degrading TIMP-1, reducing its inhibition of MMP-9 and promoting collagen degradation.

This study uses transcriptome-wide association analysis to identify 114 genes associated with coronary artery disease, including 18 novel genes, and shows they are enriched in lipid metabolism pathways.

A coronary artery disease GWAS of 181,522 cases among 1,165,690 participants yields 241 associations (54 new); an eight-predictor consensus nominates 185 candidate causal genes, 94 with ≥3 predictors.

This study identifies a genome-wide significant association between a variant in the KCND3 gene and early repolarization pattern on ECG, suggesting a genetic basis for this trait.

The paper identifies cis-epistasis at the LPA locus involving two SNPs that interact to modulate coronary artery disease risk and related traits.