Mengmeng Zhou

Phosphorylation-induced SUMOylation promotes Ulk4 condensation at ciliary tip to transduce Hedgehog signal

This study shows phosphorylation-induced SUMOylation of Ulk4 promotes its condensation at the ciliary tip, facilitating Hedgehog signal transduction by recruiting Stk36 and Gli2.

The Hippo pathway effector YAP inhibits NF-kB signaling and ccRCC growth by opposing ZHX2

This study shows YAP inhibits NF-κB signaling and ccRCC growth by blocking ZHX2, a co-factor of NF-κB, and competes with ZHX2 for binding to p65.

Ulk4 promotes Shh signaling by regulating Stk36 ciliary localization and Gli2 phosphorylation

This study identifies Ulk4's role in promoting Shh signaling by regulating Stk36 localization and Gli2 phosphorylation at the ciliary tip.