The Hippo pathway effector YAP inhibits NF-kB signaling and ccRCC growth by opposing ZHX2
Xu Li, Yong Suk Cho, Yuhong Han, Mengmeng Zhou, Yuchen Liu, Yingzi Yang, Shu Zhuo, Jin Jiang
This study shows YAP inhibits NF-κB signaling and ccRCC growth by blocking ZHX2, a co-factor of NF-κB, and competes with ZHX2 for binding to p65.
Journal of Biological Chemistry · Mar 20, 2025Peer-reviewedCancer Biology