Idan Rosh

iPSC-derived extracellular vesicles rescue deficits in human and mouse models of Parkinsons disease

The paper shows that extracellular vesicles from healthy iPSCs can reverse Parkinson's disease-related deficits in human and mouse models.

Extracellular Vesicles from Stem cells Rescue Cellular Phenotypes and Behavioral Deficits in SHANK3-Associated ASD Neuronal and Mouse Models

This study shows that EVs from stem cells can rescue cellular and behavioral deficits in Shank3-deficient models of ASD.

Divergent Excitability of GABAergic Neurons Derived from Bipolar Disorder Patients Shapes Energy Shifts of Network Dynamics, possibly mimicking mania and depression

This study compares lithium-responsive and non-responsive bipolar disorder patients' GABAergic neurons, showing divergent excitability that drives network state shifts, potentially linked to mood episodes.

Dysregulation of Multiple Solute Carrier genes and Metabolic Deficits in SLC1A4-Mutant Human iPSC-Derived Hippocampal Neurons

This study investigates SLC1A4 mutations in human iPSC-derived neurons, revealing metabolic and synaptic deficits linked to amino acid transport dysfunction and neurodevelopmental disorders.

WWOX deficiency impairs neurogenesis and neuronal function in human organoids

This study identifies WWOX mutations' impact on neurogenesis and neuronal function in human organoids, showing gene therapy can restore function.

Predicting Suicide Risk in Bipolar Disorder patients from Lymphoblastoid Cell Lines genetic signatures

This paper identifies genetic signatures in lymphoblastoid cell lines associated with suicide risk in bipolar disorder patients using RNA sequencing and machine learning.

Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission

This study compares neuronal phenotypes from monozygotic twins discordant for schizophrenia, finding differences in synaptic activity and neuronal maturation between affected and unaffected siblings.

Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations

The paper shows that cortical neurons from ASD-associated mutations exhibit early maturation and hyperexcitability compared to controls.

Synaptic dysfunction and dysregulation of extracellular matrix-related genes in dopaminergic neurons derived from Parkinson's disease sporadic patients and with GBA1 mutations

This study examines electrophysiological and gene expression changes in dopaminergic neurons from Parkinson's disease patients and those with GBA1 mutations, identifying synaptic dysfunction and ECM pathway dysregulation.

Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson's disease patients with PINK1 and PARK2 mutations

Reduced synaptic activity and dysregulated extracellular matrix pathways are common phenotypes in midbrain neurons derived from sporadic and mutation-associated Parkinson's disease patients

The paper compares midbrain neurons from PD patients with mutations and sporadic PD, finding reduced synaptic activity and dysregulated extracellular matrix pathways as common features.