François Dominique Boussin

The paper establishes and characterizes IDH-mutant astrocytoma cell lines, revealing NOTCH-regulated plasticity between astrocyte-like and oligodendrocyte-like states.

This paper develops a vascularized cerebral organoid model with microglia to study glioma stem cell interactions and radiotherapy response.

This study identifies endothelin signaling via EDNRB as a regulator of glioma cell proliferation and proneural-to-mesenchymal transition, with distinct receptor expression and functional roles in different tumor subtypes.

The paper identifies an immature neuroblast population with plasticity and molecular switches in splicing regulators during neurogenesis.