Author
University of California, San FranciscoORCID 0000-0002-7342-0108Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Wen Li, Suman Rimal, Sunil Bhurtel, Lucas Yeung, Benjamin G. Lu, Lea T. Grinberg, Salvatore Spina, Inma Cobos, William W. Seeley, Su Guo, Bingwei Lu
This study shows that tau regulates mitochondrial reverse electron transport, leading to ROS production and neurodegeneration, and identifies potential therapeutic targets.
Neuron · Aug 6, 2026Peer-reviewedNeuroscience
Jian Zhong, Ryan Gregory Natan, Qinrong Zhang, Justin S. J. Wong, Christoph Miehl, Krishnashish Bose, Xiaoyu Lu, François St-Pierre, Su Guo, Brent Doiron, Kevin K. Tsia, Na Ji
The paper introduces FACED 2.0, a high-speed imaging technique that enables simultaneous voltage and calcium activity recording in vivo across large neuronal populations.
Nature Methods · Dec 9, 2025Peer-reviewedNeuroscience
Xiang Zhao, Vincent Mouilleau, Yiqi Wang, Ahmet Can Solak, Jason Q. Garcia, Xinye Chen, Xiaoyu Shi, Christopher J. Wilkinson, Löıc A. Royer, Zhiqiang Dong, Su Guo
This study shows that Pcm1 regulates asymmetric endosome dynamics and RGP fate by coordinating Rab5b and Rab11a endosome markers and Par-3/dynein complexes in zebrafish and human brain organoids.
Nature Communications · Nov 28, 2025Peer-reviewedCell Biology
Mathieu Daynac, Vincent Mouilleau, Yuxi Liu, Xiaoyu Yang, Yin Shen, Su Guo
This study uses human iPSC-derived models to show AGTR1 inhibition protects mDA neurons from degeneration and reduces alpha-synuclein pathology.
bioRxiv · Nov 18, 2025 · PreprintNeuroscience
Krishnashish Bose, Karnika Bhardwaj, Su Guo
The paper identifies a neural mechanism in dopamine-deficient zebrafish linking stress-induced sensory processing to motor control through hyperactive brain regions.
bioRxiv · Jun 30, 2025 · PreprintNeuroscience
Jiale Xu, Romelo Casanave, Apurva S. Chitre, Qiyang Wang, Khai‐Minh Nguyen, Chiara Blake, Mahendra D. Wagle, Riyan Cheng, Oksana Polesskaya, Abraham A. Palmer, Su Guo
The paper identifies genetic loci associated with motivated behavior in zebrafish and links them to psychiatric risk genes in humans.
bioRxiv · Sep 6, 2023 · PreprintNeuroscience
Mahdi Zarei, Dan Xie, Fei Jiang, Adil Bagirov, Bo Huang, Ashish Raj, Srikantan S. Nagarajan, Su Guo
The paper finds that high neuronal activity and high functional connectivity are mutually exclusive in both zebrafish and human brains using calcium imaging and fMRI data.
BMC Biology · Apr 11, 2022Peer-reviewedNeuroscience
Matthew Lovett-Barron, Ritchie Chen, Susanna Bradbury, Aaron S. Andalman, Mahendra D. Wagle, Su Guo, Karl A. Deisseroth
The paper identifies hypothalamic circuits involved in rapid threat avoidance in zebrafish using neural activity imaging and gene expression analysis.
Nature Neuroscience · Jun 22, 2020Peer-reviewedNeuroscience