Revansiddha H. Katte

Peptide inhibitors recognize prefusion viral fusion proteins with heterogeneous stoichiometry and rapid kinetics

This study uses single-molecule imaging to show peptide inhibitors bind to prefusion viral fusion proteins with varying stoichiometry and rapid kinetics, challenging the canonical prehairpin-intermediate model.

Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

This study uses single-molecule FRET to show that gp41-directed antibodies stabilize or open the prefusion-closed state of HIV-1 Env, revealing two neutralization mechanisms.

Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening

This study visualizes the conformational changes of the HIV-1 fusion peptide during CD4-induced Env opening, showing it remains antibody accessible despite Env opening.

HIV-1-envelope trimer transitions from prefusion-closed to CD4-bound-open conformations through an occluded-intermediate state

This study identifies an occluded-intermediate state in the HIV-1 Env trimer transition pathway using molecular dynamics and smFRET, revealing new structural features and antibody recognition.