Tongqing Zhou

Endothelial protein C receptor is an entry receptor for Langya and related parahenipaviruses

The paper identifies endothelial protein C receptor (EPCR) as an entry receptor for Langya and related parahenipaviruses and describes the structural basis of this interaction.

VIProDesign: Viral Protein Panel Design for Highly Variable Viruses to Evaluate Immune Responses and Identify Broadly Neutralizing Antibodies

VIProDesign is a computational tool that designs viral protein panels to balance diversity and size, enabling better evaluation of immune responses and identification of broadly neutralizing antibodies.

Vaccine imprinting drives increased SARS-CoV-2 variant infection in children

The paper shows that vaccine imprinting influences susceptibility to SARS-CoV-2 variants in children by linking immune history, antibody neutralization, and infection risk.

pr-independent biogenesis of infectious mature Zika virus particles

This study shows that Zika virus particles can form without the prM protein and proteolytic activation, and M-E vaccines induce neutralizing antibodies regardless of maturation state.

Anti-Malaria Antibody Engineering Broadens Recognition Motifs and Reveals New Homotypic Interactions that Enhance Protective Breadth

This paper improves an anti-malaria antibody to broaden its recognition of malaria parasite proteins and enhances its protective effectiveness against diverse strains.

Protective immunity against malaria by a nanoparticle CIS43-based junctional vaccine alone or in combination with R21

This paper develops a nanoparticle-based junctional vaccine targeting PfCSP and compares its efficacy to the R21 vaccine in reducing malaria liver burden in mice.

Vaccine Elicitation of HIV-1 Neutralizing Antibodies Against Both V2 Apex and Fusion Peptide in Rhesus Macaques

This study designs a dual-epitope vaccine targeting HIV-1 Env's fusion peptide and V2 apex, showing it elicits neutralizing antibodies against both sites in rhesus macaques.

Novel HIV-1 fusion peptide immunogens using glycan-engineered alphavirus-like particles

This paper develops glycan-engineered alphavirus-like particles as HIV-1 fusion peptide immunogens, showing improved antibody responses and neutralization against multi-clade HIV-1.

Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques

This study shows that macaques can elicit human-like broadly neutralizing antibodies against influenza HA stem regions, with similar immunogenetic and structural features.

BRAVE: a highly accurate method for predicting HIV-1 antibody resistance using large language models for proteins

BRAVE predicts HIV-1 resistance to 33 bNAbs using a Random Forests classifier with a protein language model, outperforming existing tools in accuracy and other metrics.

Transient glycan-shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques

This study shows that transient glycan deletions in SHIVs can induce CD4-binding site broadly neutralizing antibodies in macaques, offering a model for HIV vaccine design.

GLYCO-2: a Tool to Quantify Glycan Shielding of Glycosylated Proteins with Improved Data Processing and Computation Speed

GLYCO-2 improves computational efficiency for quantifying glycan shielding of glycoproteins, revealing increased shielding in influenza HA proteins over time.

HKU5 bat merbecoviruses use divergent mechanisms to engage bat and mink ACE2 as entry receptors

This study identifies bat and mink ACE2 as receptors for HKU5 merbecovirus, revealing distinct receptor interactions and highlighting mustelids as potential intermediate hosts.

HIV-1-envelope trimer transitions from prefusion-closed to CD4-bound-open conformations through an occluded-intermediate state

This study identifies an occluded-intermediate state in the HIV-1 Env trimer transition pathway using molecular dynamics and smFRET, revealing new structural features and antibody recognition.

Structural survey of HIV-1-neutralizing antibodies targeting Env trimer delineates epitope categories and suggests vaccine templates

The paper analyzes HIV-1 broadly neutralizing antibodies to classify epitopes and identify potential vaccine candidates based on structural and immunological features.