Gorka Gereñu

This study shows that ARC acts as a retroviral-like capsid for TDP-43 spreading in ALS and FTD, and that Lenacapavir blocks this process.

This study uses computational methods to analyze ELOVL6 structure and inhibition, identifying key residues and binding pathways for drug design.

This study shows that GRN haploinsufficiency in FTD causes lysosomal and mitochondrial dysfunction, lipid metabolism changes, and autophagy impairment, which may contribute to disease pathogenesis.

This study identifies Trx80 as a neuron-derived peptide that modulates microglia interferon response via Trem2-dependent mechanisms in Alzheimer's disease models.