Jack F. Cazet

ARMC1 regulates mitochondrial fatty acid oxidation through theinsertase/scramblase MTCH2

This study identifies ARMC1 as a regulator of mitochondrial fatty acid oxidation through its interaction with MTCH2, showing that this interaction suppresses FAO during starvation.

A Molecular, Spatial, and Regulatory Atlas of the Hydra vulgaris Nervous System

This study characterizes the nervous system of Hydra vulgaris using scRNA-seq, identifying 15 neuron subtypes, mapping their spatial distribution, and exploring regulatory mechanisms through ATAC-seq and trajectory inference.

New Hydra Genomes Reveal Conserved Principles of Hydrozoan Transcriptional Regulation

This study generates new Hydra genomes and transcriptomic resources to uncover conserved transcriptional regulatory mechanisms in cnidarians.

Differential gene regulation in DAPT-treated Hydra reveals molecular pathways dependent on Notch signalling during interstitial cell differentiation and formation of the oral-aboral axis in Hydra.

This study uses RNAseq to identify genes differentially regulated by Notch signaling inhibition in Hydra, revealing roles in nematocyte development and head organizer formation.

Oral Regeneration Is the Default Pathway Triggered by Injury in Hydra

The paper shows that injury in Hydra triggers an initial generalized response involving Wnt signaling, which later becomes restricted to oral regeneration, with TCF required for both oral and aboral regeneration.

PIWI-piRNA pathway-mediated transposable element repression in Hydra somatic stem cells

This study shows the PIWI-piRNA pathway represses transposable elements in Hydra epithelial stem cells, preventing genomic damage and maintaining tissue integrity.

Stem cell differentiation trajectories in Hydra resolved at single-cell resolution

This study maps stem cell differentiation trajectories in Hydra using single-cell transcriptomics, revealing shared progenitor states for neurons and gland cells and creating a gene expression map of the nervous system.