Celina E. Juliano

This study shows sustained ERK signaling is critical for Wnt pathway activation during Hydra head regeneration and highlights evolutionary divergence in ERK-Wnt regulatory mechanisms between species.

This study identifies Wnt signaling as critical for foot regeneration in Hydra, showing its restoration can rescue regeneration in a species that otherwise lacks this ability.

This study characterizes the nervous system of Hydra vulgaris using scRNA-seq, identifying 15 neuron subtypes, mapping their spatial distribution, and exploring regulatory mechanisms through ATAC-seq and trajectory inference.

This study uses cell-type specific imaging in Hydra to show that neurons differentiate terminally before re-establishing functional neural circuits during regeneration.

This study generates new Hydra genomes and transcriptomic resources to uncover conserved transcriptional regulatory mechanisms in cnidarians.

The paper uses single-cell RNA sequencing to analyze zebrafish ovarian cells, identifying novel cell subpopulations and gene functions involved in ovarian development.

This study identifies two distinct neuronal networks in Hydra vulgaris that coordinate mechanosensory responses, revealing how sensory information is processed in a radially symmetric nervous system.

This study uses RNAseq to identify genes differentially regulated by Notch signaling inhibition in Hydra, revealing roles in nematocyte development and head organizer formation.

The paper shows that injury in Hydra triggers an initial generalized response involving Wnt signaling, which later becomes restricted to oral regeneration, with TCF required for both oral and aboral regeneration.

This study shows the PIWI-piRNA pathway represses transposable elements in Hydra epithelial stem cells, preventing genomic damage and maintaining tissue integrity.

This study maps stem cell differentiation trajectories in Hydra using single-cell transcriptomics, revealing shared progenitor states for neurons and gland cells and creating a gene expression map of the nervous system.