Svetlana Dodonova

Structural basis of nucleosome remodeling by archaeal RNA polymerase during transcription elongation

This study reveals how archaeal RNA polymerase remodels nucleosomes during transcription elongation by redirecting DNA and displacing histones, using cryo-EM structures of a Pyrococcus furiosus complex.

Emergence of histone-based chromatin complexity in Asgard archaea

This study identifies histone-based chromatin regulation components in Asgard archaea, suggesting these features predate eukaryogenesis.

Cryo-electron tomography reveals near-native archaeal chromatin architecture

This study uses cryo-electron tomography to reveal the dynamic chromatin architecture of archaea, showing variable hypernucleosome structures and growth-phase-dependent organization.

Cryo-EM reveals open and closed Asgard chromatin assemblies

This study presents the first cryo-EM structures of Asgard chromatin assemblies, revealing closed and open hypernucleosome conformations and their evolutionary implications.

The interaction landscape between transcription factors and the nucleosome

The paper investigates how transcription factors interact with nucleosomal DNA, finding that most have less access to it than free DNA and that nucleosome structure affects motif positioning and orientation.