Cheng Zhou

The paper uses single-nucleus RNA sequencing and spatial transcriptomics to classify adult human spinal cord neurons into 21 subclusters and compare them with mouse data, revealing similarities and sex differences.

This study identifies reactive astrocytes controlled by Wnt5a signaling as critical for opioid-induced hyperalgesia development in mice.

The paper compares glial cell transcriptomes between human and mouse peripheral and central nervous systems, revealing divergence in subcluster numbers and gene expression patterns.

This study generates the first comprehensive single-nucleus RNA-seq atlas of human spinal cord neurons, identifying 18 clusters and novel marker genes, and comparing them to mouse data.

This study shows that increased NALCN expression contributes to neuropathic pain and suggests NALCN as a potential therapeutic target.