Shao‐Jun Tang

Nucleoside reverse transcriptase inhibitors are the major class of HIV antiretroviral therapeutics that induce neuropathic pain in Mice

This study identifies nucleoside reverse transcriptase inhibitors (NRTIs) as the primary class of antiretrovirals causing neuropathic pain in mice, highlighting their role in peripheral sensory neuropathy.

Development of opioid-induced hyperalgesia depends on reactive astrocytes controlled by Wnt5a signaling

This study identifies reactive astrocytes controlled by Wnt5a signaling as critical for opioid-induced hyperalgesia development in mice.

A novel subtype of reactive astrocytes critical for HIV associated pain pathogenesis

The paper identifies a novel subtype of reactive astrocytes, HIPAs, critical for HIV-associated pain pathogenesis in mice and humans.

Microglial ablation does not affect opioid-induced hyperalgesia in rodents

This study shows that microglial ablation does not impair opioid-induced hyperalgesia in rodents, challenging the assumption of microglial involvement in this condition.

Mechanism and role of astrogliosis in the pathogenesis of HIV-associated pain

This study identifies a novel mechanism by which astrogliosis contributes to HIV-associated pain through Wnt5a signaling and IL-1β regulation.

Drosophila model of Anti-retroviral therapy Induced Peripheral Neuropathy and Nociceptive Hypersensitivity

This study develops a Drosophila model to investigate NRTI-induced peripheral neuropathy and nociceptive hypersensitivity, finding that increased neuronal dynamics contribute to these effects.

Single cell RNA-seq analysis reveals compartment-specific heterogeneity and plasticity of microglia

This study uses scRNA-seq to compare microglia in adult mouse brains and spinal cords, identifying subtype differences and plasticity in response to HIV-1 gp120.