Jin Liu

Pharmacological recruitment of a VTA glutamatergic arousal circuit by the natural product BN3 drives broad-spectrum emergence from general anesthesia

The paper identifies BN3 as a broad-spectrum agent that accelerates emergence from general anesthesia by targeting a VTA glutamatergic arousal circuit.

TRPV4 Inhibition by a Natural Product Mediates Analgesia

This study identifies AH001 as a potent TRPV4 inhibitor, revealing its mechanism and demonstrating its analgesic effects in pain models.

Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord

The paper uses single-nucleus RNA sequencing and spatial transcriptomics to classify adult human spinal cord neurons into 21 subclusters and compare them with mouse data, revealing similarities and sex differences.

Single-nucleus transcriptomic analysis reveals divergence of glial cells in peripheral somatosensory system between human and mouse

The paper compares glial cell transcriptomes between human and mouse peripheral and central nervous systems, revealing divergence in subcluster numbers and gene expression patterns.

Single-nucleus transcriptomic atlas of spinal cord neuron in human

This study generates the first comprehensive single-nucleus RNA-seq atlas of human spinal cord neurons, identifying 18 clusters and novel marker genes, and comparing them to mouse data.

Sodium leak channel as a therapeutic target for neuronal sensitization in neuropathic pain

This study shows that increased NALCN expression contributes to neuropathic pain and suggests NALCN as a potential therapeutic target.

Astroglial dysfunctions drive aberrant synaptogenesis in developing brain with lengthy general anesthesia

This study shows that sevoflurane exposure disrupts astrocyte function, leading to synaptic overgrowth and dysfunction in developing brains.