Donghang Zhang

Volatile anaesthetics modulate voltage-gated sodium channel function at a site critical for gating

This study identifies a volatile anaesthetic binding site in voltage-gated sodium channels, showing it modulates channel function and reduces neuronal excitability.

Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord

The paper uses single-nucleus RNA sequencing and spatial transcriptomics to classify adult human spinal cord neurons into 21 subclusters and compare them with mouse data, revealing similarities and sex differences.

Development of opioid-induced hyperalgesia depends on reactive astrocytes controlled by Wnt5a signaling

This study identifies reactive astrocytes controlled by Wnt5a signaling as critical for opioid-induced hyperalgesia development in mice.

Single-nucleus transcriptomic analysis reveals divergence of glial cells in peripheral somatosensory system between human and mouse

The paper compares glial cell transcriptomes between human and mouse peripheral and central nervous systems, revealing divergence in subcluster numbers and gene expression patterns.

Single-nucleus transcriptomic atlas of spinal cord neuron in human

This study generates the first comprehensive single-nucleus RNA-seq atlas of human spinal cord neurons, identifying 18 clusters and novel marker genes, and comparing them to mouse data.

Sodium leak channel as a therapeutic target for neuronal sensitization in neuropathic pain

This study shows that increased NALCN expression contributes to neuropathic pain and suggests NALCN as a potential therapeutic target.