Flavio Cargnin Faccin

This study shows that H5N1 viruses from B3.13 and D1.1 lineages have reduced infectivity in human respiratory cultures due to impaired neuraminidase and polymerase activities, suggesting lower pandemic risk than traditional models indicate.

This paper develops an in vitro aerosol exposure system to study influenza virus infectivity in different cell types and identifies differences in airborne infectivity among virus strains.

This study shows that dispersal within the respiratory tract affects viral genetic diversity and evolutionary potential, with nasal and tracheal regions maintaining diversity while lung regions show genetic distinctness.