Daniel Roberto Perez

IMPAIRED NEURAMINIDASE AND POLYMERASE ACTIVITIES CORRESPOND WITH LIMITED AEROSOL INFECTIVITY OF B3.13 AND D1.1 H5N1 LINEAGES IN HUMAN RESPIRATORY CULTURES

This study shows that H5N1 viruses from B3.13 and D1.1 lineages have reduced infectivity in human respiratory cultures due to impaired neuraminidase and polymerase activities, suggesting lower pandemic risk than traditional models indicate.

Impact of Maternal Antibodies and Weaning Stress on the Replication and Transmission of Human H3N2 Influenza A in Piglets

This study examines how maternal antibodies and weaning stress affect piglets' susceptibility to human H3N2 influenza A virus, showing that matched maternal antibodies reduce shedding and transmission while weaning increases viral spread.

Vaccine-induced antigenic drift of a human-origin H3N2 Influenza A virus in swine alters glycan binding and sialic acid avidity

This study shows vaccine-induced immunity drives antigenic drift in a human-origin H3N2 virus in swine, altering HA receptor binding and glycan specificity.

Passage of human-origin influenza A virus in swine tracheal epithelial cells selects for adaptive mutations in the hemagglutinin gene

This study shows that serial passage of a human-origin H3N2 virus in swine tracheal epithelial cells selects for adaptive HA mutations that increase viral fitness in swine cells.

Air-Liquid Interface Model for Influenza Aerosol Exposure In Vitro

This paper develops an in vitro aerosol exposure system to study influenza virus infectivity in different cell types and identifies differences in airborne infectivity among virus strains.

Dispersal of influenza virus populations within the respiratory tract shapes their evolutionary potential

This study shows that dispersal within the respiratory tract affects viral genetic diversity and evolutionary potential, with nasal and tracheal regions maintaining diversity while lung regions show genetic distinctness.