C. Joaquín Cáceres

This study examines sialic acid receptor distribution and H5N1 virus binding in sheep, goats, and alpacas, finding species-specific differences in receptor abundance and virus binding.

This study shows that H5N1 viruses from B3.13 and D1.1 lineages have reduced infectivity in human respiratory cultures due to impaired neuraminidase and polymerase activities, suggesting lower pandemic risk than traditional models indicate.

This study shows vaccine-induced immunity drives antigenic drift in a human-origin H3N2 virus in swine, altering HA receptor binding and glycan specificity.

This study uses lectin histochemistry to examine sialic acid receptor distribution in mammary glands of livestock and humans, finding SA 2,6-Gal and SA 2,3-Gal receptors that enable IAV binding.

This paper develops an in vitro aerosol exposure system to study influenza virus infectivity in different cell types and identifies differences in airborne infectivity among virus strains.

This study shows that dispersal within the respiratory tract affects viral genetic diversity and evolutionary potential, with nasal and tracheal regions maintaining diversity while lung regions show genetic distinctness.

This paper develops a modified live influenza virus vaccine (RAM-IGIP) that enhances humoral and mucosal immunity against influenza, showing complete protection in mice.