Jorian J. Sepers

GCK-4 regulates apical actin organization and lumen formation in the C. elegans intestine

This study identifies GCK-4 as a regulator of apical actin and junction organization in C. elegans intestine lumen formation, showing it acts independently of ERM phosphorylation.

The mIAA7 degron improves auxin-mediated degradation in C. elegans

The paper introduces the mIAA7 degron, which enhances auxin-mediated protein degradation efficiency in C. elegans, with some improvements in leakiness when combined with the C.e.AID2 system.

Systemic coagulopathy drives host lethality in a new Drosophila tumor model

This study shows that a Drosophila tumor model induces coagulopathy phenotypes similar to human patients, with hypercoagulation followed by hypocoagulation, and demonstrates that rescuing coagulopathy improves survival.