Author

Mahadevappa Hemshekhar

Red River CollegeORCID 0000-0002-5016-501XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Neeloffer MookherjeeiD· 3 shared Padmanie Ramotar· 3 shared Anne M. van der DoesiD· 2 shared Anthony AltieriiD· 2 shared Christopher D. PascoeiD· 2 shared Courtney Lynn Marshall· 1 shared Dina H. D. Mostafa· 1 shared Dylan Lloyd· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

Neeloffer MookherjeeORCID

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3 papers

Recent·Most cited

LL-37 and Citrullinated-LL-37 elicited Transcriptome and Cytokine Profiles in Human Bronchial Epithelial Cells: Citrullination dampens the inflammatory biosignature

Padmanie Ramotar, Dina H. D. Mostafa, Mahadevappa Hemshekhar, Courtney Lynn Marshall, Christopher D. Pascoe, Neeloffer Mookherjee

This study compares the transcriptome and cytokine profiles of human bronchial epithelial cells stimulated with LL-37 and its citrullinated form, finding that citrullination reduces the inflammatory response.

bioRxiv · Sep 25, 2026 · PreprintImmunology

LL-37 and citrullinated-LL-37 enhance disparate oxylipins: LL-37-mediated chemokine response is dependent on COX-2 and the P2X7 receptor in human bronchial epithelial cells

Padmanie Ramotar, Mahadevappa Hemshekhar, Anthony Altieri, Anne M. van der Does, Christopher D. Pascoe, Neeloffer Mookherjee

This study shows LL-37 enhances pro-inflammatory oxylipins and chemokines via COX-2 and P2X7 receptor, while citrullinated LL-37 reduces these effects.

bioRxiv · Oct 30, 2025 · PreprintImmunology

LL-37 modulates IL-17A/F-mediated airway inflammation by selectively suppressing Lipocalin-2.

Anthony Altieri, Dylan Lloyd, Padmanie Ramotar, Anne M. van der Does, Mahadevappa Hemshekhar, Neeloffer Mookherjee

This study shows LL-37 and its citrullinated form suppress IL-17A/F-induced LCN-2 production in bronchial epithelial cells, reducing neutrophil migration and airway inflammation.

Journal of Inflammation · May 23, 2025Peer-reviewedImmunology