Christopher D. Pascoe

LL-37 and Citrullinated-LL-37 elicited Transcriptome and Cytokine Profiles in Human Bronchial Epithelial Cells: Citrullination dampens the inflammatory biosignature

This study compares the transcriptome and cytokine profiles of human bronchial epithelial cells stimulated with LL-37 and its citrullinated form, finding that citrullination reduces the inflammatory response.

Plasma-derived extracellular vesicles as potential biomarkers and mediators of functional alterations in MELAS

This study investigates plasma-derived extracellular vesicles as biomarkers for MELAS and their functional impact on mitochondrial respiration in skeletal muscle myotubes.

Autophagy Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in Glioma

This study shows that autophagy and cholesterol metabolism are remodeled in glioma progression and TMZ resistance, with impaired autophagy linked to reduced cholesterol synthesis and altered lipid profiles.

LL-37 and citrullinated-LL-37 enhance disparate oxylipins: LL-37-mediated chemokine response is dependent on COX-2 and the P2X7 receptor in human bronchial epithelial cells

This study shows LL-37 enhances pro-inflammatory oxylipins and chemokines via COX-2 and P2X7 receptor, while citrullinated LL-37 reduces these effects.

Novel DNA methylation changes in mouse lungs associated with heavy smoking

This study identifies 32 differentially methylated genes in mouse lungs associated with heavy smoking, revealing novel links to nicotine dependency, tumorigenesis, and COPD.

Early life exposure to cigarette smoke primes lung function changes and DNA methylation changes at Cyp1a1 upon exposure later in life

This study shows that prenatal and early postnatal cigarette smoke exposure in mice leads to long-term lung function and DNA methylation changes at Cyp1a1, which can be reestablished upon adult re-exposure.

Proteomic Profiling of Hypoplastic Lungs Suggests an Underlying Inflammatory Response in the Pathogenesis of Abnormal Lung Development in Congenital Diaphragmatic Hernia

The paper uses proteomic profiling to identify inflammatory processes as a key factor in the pathogenesis of lung hypoplasia in congenital diaphragmatic hernia.

Integrating Proteomes for Lung Tissue and Lavage Reveals Pathways that Link Responses in Allergen-Challenged Mice

The paper integrates proteomes from lung tissue and BALF in allergen-challenged mice to identify compartment-specific and shared biological pathways involved in allergic asthma responses.