Uri Y. Tabori

The paper uses single-cell and spatial multi-omic analyses to characterize cellular diversity in RTK-fused gliomas across pediatric age groups, identifying distinct cancer cell states and myeloid subgroups.

This study examines hTERT expression and its prognostic impact in pediatric medulloblastoma, finding higher expression correlates with worse survival outcomes.

The paper identifies functionally distinct ALK and ROS1 fusions in infant-type hemispheric gliomas, showing they converge on STAT3 and SHP2 activation through different mechanisms.

This study identifies DNA-PK as a synthetic lethal target in TP53-deficient SHH medulloblastoma, showing that inhibiting DNA-PK enhances radiosensitivity and improves survival in preclinical models.

This paper develops a single-molecule long-read sequencing method to detect single-strand DNA mismatches and damage, revealing their relationship to double-strand mutations and providing insights into mutation mechanisms in cancer and aging.

The paper quantifies mismatch repair (MMR) activity in human tissues by analyzing mutation rates in individuals with constitutional MMR deficiency, revealing genotype-specific mutational signatures and the role of MMR components in DNA repair.