Author

Francesc Madriles

Spanish National Cancer Research CentreORCID 0000-0002-5044-0747Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Ana CuadradoiD· 1 shared Direna Alonso‐CurbeloiD· 1 shared Enrique Carrillo de Santa PauiD· 1 shared Francisco Soriano· 1 shared Francisco X. RealiD· 1 shared Irene EspositoiD· 1 shared Jaime Martínez de VillarrealiD· 1 shared Javier MuñoziD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Ana CuadradoORCID

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1 paper

Recent·Most cited

GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions

Francesc Madriles, Mónica P. de Andrés, Mikhail Chesnokov, Jaime Martínez de Villarreal, Direna Alonso‐Curbelo, Natalia del Pozo, Mar Iglesias, Enrique Carrillo de Santa Pau, Juan Iovanna, Francisco Soriano, Ana Cuadrado, Mirari Marques, Javier Muñoz, Irene Esposito, Paola Martinelli, , Francisco X. Real

This study shows that GATA4 loss in Kras-mutant mice leads to PDAC without canonical precursor lesions, identifying a new lesion type and revealing GATA4's role in inflammatory programs.

bioRxiv · May 26, 2026 · PreprintCancer Biology