Enrique Carrillo de Santa Pau

The paper identifies associations between macrophage enhancers and cardiovascular disease variants using epigenomic data from immune cells.

This study shows that GATA4 loss in Kras-mutant mice leads to PDAC without canonical precursor lesions, identifying a new lesion type and revealing GATA4's role in inflammatory programs.

FungiGutDB is a curated database for accurate gut mycobiome taxonomic assignment using whole genome sequencing, showing improved performance over standard databases in characterizing fungal communities in human microbiome studies.

The paper examines gut microbial ecosystems across different metabolic and obesity phenotypes, finding that metabolic health, not obesity, drives microbial connectivity and functional cohesion.

The paper identifies bioactive compounds that may counteract cancer gene-expression profiles in colorectal cancer subgroups using epigenomic and transcriptomic data.

The paper identifies microbial genera associated with diet quality and diabetes risk using microbiome data and machine learning.

The paper identifies potential colorectal cancer biomarkers from the gut microbiome of obese individuals using machine learning and network biology.

The paper investigates how 3D chromatin structure and chromatin environment influence DNA replication origin activation efficiency in mouse embryonic stem cells under stress and control conditions.

The paper maps the epigenomic and functional changes during human neutrophil differentiation from bone marrow progenitors to mature cells, revealing key regulatory mechanisms.

This study compares the epigenomes of neutrophils and monocytes to identify regulatory elements and chromatin states, revealing differences in enhancer activity and DNA methylation.

The paper develops a bioinformatic workflow to classify blood epigenomes by cell type and identifies chromatin determinant regions linked to cell identity and disease.

The paper measures and compares transcriptional and epigenetic variability across immune cell types and finds neutrophils exhibit higher variability linked to immune pathways and environmental exposure.

The paper identifies 5hmC as a central hub in the chromatin network of ESCs, linking DNA demethylation to chromatin remodeling and pluripotency factors through epigenomic co-localization and co-evolution analysis.