Natalia del Pozo

This study shows that GATA4 loss in Kras-mutant mice leads to PDAC without canonical precursor lesions, identifying a new lesion type and revealing GATA4's role in inflammatory programs.

This study identifies ΔNP63 as a marker for exocrine-committed multipotent progenitors in the murine pancreas, showing its role in exocrine development and differentiation.

This paper shows a CTRB2 deletion variant increases pancreatic cancer risk by causing ER stress and inflammation in mice, using a new genetic model.

This study uses single-cell RNA sequencing to map the in vivo reprogramming trajectory from acinar cells to pluripotency in the pancreas and identifies conserved intermediate markers across tissues.

This study shows HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancer by remodeling enhancers and inhibiting oncogenic pathways.

This study shows NR5A2 regulates both cell differentiation and inflammation in the pancreas, with its loss leading to a pre-inflammatory state and impaired regeneration.