Ana Cuadrado

GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions

This study shows that GATA4 loss in Kras-mutant mice leads to PDAC without canonical precursor lesions, identifying a new lesion type and revealing GATA4's role in inflammatory programs.

Integrative multi-omics reveals PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcoma.

This study identifies PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcoma through multi-omics analyses and functional experiments.

Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF

This study shows that CTCF is essential for establishing 3D chromatin structure and regulating metabolic and protein homeostasis during early mouse development, but these functions operate independently.

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization

This study investigates the distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization in non-transformed human cells, showing SA1 stabilizes TAD boundaries while SA2 facilitates enhancer-promoter interactions.