Francisco X. Real

This study shows that GATA4 loss in Kras-mutant mice leads to PDAC without canonical precursor lesions, identifying a new lesion type and revealing GATA4's role in inflammatory programs.

This study identifies NGFR as a marker of a basal BLCA subpopulation associated with poor prognosis and reduced immunotherapy response.

This study identifies novel genetic risk loci for pancreatic ductal adenocarcinoma in African ancestry individuals through admixture mapping and GWAS.

This study identifies ΔNP63 as a marker for exocrine-committed multipotent progenitors in the murine pancreas, showing its role in exocrine development and differentiation.

This paper develops a consensus molecular classifier for pancreatic ductal adenocarcinoma by integrating tumor and stroma features, achieving high accuracy in predicting overall survival.

This study shows that STAG2 cohesin works with DREAM to maintain quiescence and prevent tumor formation in urothelial cells by regulating chromatin structure and cell cycle control.

This paper shows a CTRB2 deletion variant increases pancreatic cancer risk by causing ER stress and inflammation in mice, using a new genetic model.

This study benchmarks spatial transcriptomics and proteomics platforms across six cancer types, identifying platform-specific strengths and limitations in data quality and biological insights.

This study shows BPTF works with MYCN and MYC to control cell cycle and epigenetic states in neuroblastoma, linking it to poor prognosis and therapeutic potential.

This study uses single-cell RNA sequencing to map the in vivo reprogramming trajectory from acinar cells to pluripotency in the pancreas and identifies conserved intermediate markers across tissues.

The paper uses a multi-layered approach combining GWAS, spatial autocorrelation, and Hi-C to identify novel genetic variants associated with pancreatic cancer susceptibility.

This study investigates the role of STAG2 cohesin in heart development by analyzing Stag2-ablated mice, finding essential roles in cardiac transcriptional programs and heart tube formation.

This study shows HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancer by remodeling enhancers and inhibiting oncogenic pathways.

matchSCore matches cell populations across tools, experiments, and technologies by comparing clustering and marker gene identification accuracy in simulated data and applying it to mouse and human cell atlas projects.

This study establishes a method to propagate urothelial organoids from Cd49f-high stem cells and identifies Notch signaling as critical for their differentiation.

This study identifies a synthetic lethal interaction between STAG1 and STAG2 in cancers with STAG2 mutations, suggesting STAG1 as a therapeutic target.