Jaime Martínez de Villarreal

GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions

This study shows that GATA4 loss in Kras-mutant mice leads to PDAC without canonical precursor lesions, identifying a new lesion type and revealing GATA4's role in inflammatory programs.

Nerve growth factor receptor identifies a basal subpopulation linked to poor prognosis and reduced immunotherapy responses in bladder cancer

This study identifies NGFR as a marker of a basal BLCA subpopulation associated with poor prognosis and reduced immunotherapy response.

STAG2 cohesin cooperates with DREAM to maintain quiescence and suppress tumourigenesis in the urothelium

This study shows that STAG2 cohesin works with DREAM to maintain quiescence and prevent tumor formation in urothelial cells by regulating chromatin structure and cell cycle control.

A common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice

This paper shows a CTRB2 deletion variant increases pancreatic cancer risk by causing ER stress and inflammation in mice, using a new genetic model.

Deciphering the roadmap of in vivo reprogramming towards pluripotency

This study uses single-cell RNA sequencing to map the in vivo reprogramming trajectory from acinar cells to pluripotency in the pancreas and identifies conserved intermediate markers across tissues.