Thomas B. Thompson

GDF3 is an endogenous antagonist of the ActE-ALK7/ACVR2 pathway in adipocytes

This study identifies GDF3 as an endogenous inhibitor of the ActE-ALK7 pathway in adipocytes, showing its role in metabolic diseases like MASLD/MASH and suggesting GDF3 inhibition as a therapeutic target.

The crystal structure of the activin B:Fst288 complex and computational insights into the broad antagonistic activity and specificity of follistatin

The paper solves the crystal structure of the ActB:Fst288 complex and uses computational analysis to explain Fst288's broad antagonistic activity and specificity for activins.

Structural Basis of Non-Latent Signaling by the Anti-Mullerian Hormone Procomplex

This study reveals the structural basis of AMH procomplex signaling, showing how the prodomain maintains activity through a unique conformational mechanism.

Characterization of erythroferrone oligomerization and its impact on BMP antagonism

This study investigates how erythroferrone (ERFE) oligomerization affects its ability to inhibit BMP ligands, identifying a critical ligand binding domain essential for BMP antagonism.

Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.

The paper investigates the functional differences between GDF11 and GDF8 by substituting amino acids and identifies distinct effects on skeletal development and muscle.