Author

Amanda K. Williamson

Boston UniversityORCID 0000-0002-1840-4199Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Mark W. GrinstaffiD· 3 shared Andrew C. KruseiD· 1 shared Andrew MartiniD· 1 shared Brett M TingleyiD· 1 shared Chérine BecharaiD· 1 shared Daniel Kahne· 1 shared Danny S. RohiD· 1 shared David ZurakowskiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

Mark W. GrinstaffORCID

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3 papers

Recent·Most cited

Divergent activation of the RXFP1 relaxin receptor by protein and small molecule agonists

James Osei‐Owusu, Tristan Girbau, Xunan Wang, Jeffrey S. Smith, Pengxiang Shen, Sarah C. Erlandson, Amanda K. Williamson, Xiaojing Cong, Mark W. Grinstaff, Daniel Kahne, Chérine Bechara, Andrew C. Kruse

This study presents cryo-EM structures of RXFP1 bound to relaxin-2 and AZD5462, revealing distinct activation mechanisms for protein and small-molecule agonists.

bioRxiv · Jun 11, 2026 · PreprintBiochemistry

Universal high-throughput image quantification of subcellular structure dynamics and spatial distributions within cells

Andrew Martin, Sue Zhang, Amanda K. Williamson, Brett M Tingley, Mira Pickus, David Zurakowski, Hadi Tavakoli Nia, Orian S. Shirihai, X. S. Han, Mark W. Grinstaff

This paper introduces GRID, a high-throughput image analysis method using dispersion indices to quantify subcellular structure dynamics and spatial distributions across diverse biological contexts.

iScience · Mar 13, 2026Peer-reviewedCell Biology

Relaxin-2 drives regenerative healing and suppresses scar formation

Amanda K. Williamson, Katherine Hohl, Jack R. Kirsch, Rosalynn M. Nazarian, Thomas P. Schaer, Danny S. Roh, Mark W. Grinstaff

This study shows that relaxin-2 reduces fibrosis and promotes regenerative healing by inhibiting TGF-b1-driven ECM deposition in both in vitro and in vivo models.

bioRxiv · Dec 10, 2025 · PreprintBioengineering