James Osei‐Owusu

This study presents cryo-EM structures of RXFP1 bound to relaxin-2 and AZD5462, revealing distinct activation mechanisms for protein and small-molecule agonists.

This paper uses machine learning to predict high-affinity nanobody binders from sparse sequencing data, outperforming deep learning and semi-supervised methods with linear models.

This paper introduces GTACs, bispecific antibodies that selectively downregulate GPCRs via endocytosis and lysosomal degradation, showing high potency and selectivity for therapeutic targets.

This study shows that the proton-activated chloride channel inhibits SARS-CoV-2 entry by blocking endosomal acidification and the cathepsin-dependent pathway.