Author

A.H. Jan Danser

Erasmus MCORCID 0000-0002-5052-3585Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

Hong S. LuiD· 3 shared Adam E. MullickiD· 2 shared Alan DaughertyiD· 2 shared Dien YeiD· 2 shared Congqing WuiD· 1 shared Hisashi SawadaiD· 1 shared Hui LiniD· 1 shared Kenneth S. CampbelliD· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMolecular Biology

Hong S. LuORCID

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3 papers

Recent·Most cited

Renal Angiotensinogen in Nonhuman Primates is Predominantly Liver-Derived

Masayoshi Kukida, Lei Cai, Dien Ye, Hisashi Sawada, Yuriko Katsumata, Michael Franklin, Peter I. Hecker, Kenneth S. Campbell, A.H. Jan Danser, Adam E. Mullick, Alan Daugherty, Ryan E. Temel, Hong S. Lu

This study shows that renal angiotensinogen in nonhuman primates is mainly derived from the liver, as evidenced by reduced renal AGT levels after liver-specific AGT inhibition.

Arteriosclerosis Thrombosis and Vascular Biology · Sep 9, 2021Peer-reviewedMolecular Biology

Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression: Insights into COVID-19

Congqing Wu, Dien Ye, Adam E. Mullick, Zhenyu Li, A.H. Jan Danser, Alan Daugherty, Hong S. Lu

This study investigates whether renin-angiotensin inhibition affects ACE2 and TMPRSS2 expression in mice, finding no changes in ACE2 but a decrease in TMPRSS2 in lungs with AGT depletion.

Hypertension · Jul 15, 2020Peer-reviewedMolecular Biology

MicroRNA-148a Regulates Low-Density Lipoprotein Metabolism by Repressing the (Pro)renin Receptor

Na Wang, Lishu He, Hui Lin, Lunbo Tan, Yuan Sun, Xiaoying Zhang, A.H. Jan Danser, Hong S. Lu, Yongcheng He, Xifeng Lu

This study shows miR-148a regulates LDL metabolism by suppressing (P)RR expression, which in turn reduces LDLR abundance and cellular LDL uptake.

PLoS ONE · May 21, 2020Peer-reviewedMolecular Biology