Author

Nicolas Barois

Centre National de la Recherche ScientifiqueORCID 0000-0002-5057-1931Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:Drosophila· 2 Approach:experimental assay· 2 Assay:electronic health records· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Erwan LambertiD· 2 shared Frank LafontiD· 2 shared Jean‐Charles LambertiD· 2 shared Patrik VerstrekeniD· 2 shared Philippe AmouyeliD· 2 shared Pierre DourleniD· 2 shared Xavier Hermant· 2 shared Alejandra Freire‐RegatilloiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

Erwan LambertORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 11, 2025

BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicity

Erwan Lambert, Carla Gelle, Valentin Leclerc…·Pierre Dourlen

This study shows that BIN1 isoform 1 expression in the presynaptic compartment causes synaptotoxicity, leading to synaptic loss and structural changes in Drosophila and rat models.

DOI 10.1101/2025.08.11.669624

Drosophilarat

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NeuroscienceActa Neuropathologica CommunicationsPeer-reviewedJan 8, 2022

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects

Erwan Lambert, Orthis Saha, Bruna Soares Landeira…·Pierre Dourlen

This study shows that BIN1 isoform1 causes early endosome defects and neurodegeneration in Drosophila and human neurons, linking it to Alzheimer's disease pathology.

65 citationstop 1%

Drosophilaproteomics

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