Author

Bruna Soares Landeira

InsermORCID 0000-0001-5720-8273Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Organism:Drosophila· 1 Organism:human· 1

Frequent Co-Authors

Marcos R. CostaiD· 3 shared Alexandre PelletieriD· 2 shared Amélie BonnefondiD· 2 shared Ana Raquel Melo de FariasiD· 2 shared Arnaud CarrieriD· 2 shared Daiane Cristina Ferreira Golbert· 2 shared Fabien DelahayeiD· 2 shared Jean‐Charles LambertiD· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Marcos R. CostaORCID

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4 papers

Recent·Most cited

NeuroscienceCurrent ProtocolsPeer-reviewedJul 1, 2022

Laser Capture Microdissection optimization for high-quality RNA in mouse brain tissue

Margareth Nogueira, Daiane Cristina Ferreira Golbert, Bruna Soares Landeira, Richardson Naves Leão

The paper describes an optimized LCM protocol for extracting high-quality RNA from specific mouse brain regions.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintJan 18, 2022

The Alzheimer's disease risk gene BIN1 modulates neural network activity via the regulation of L-type calcium channel expression in human-induced neurons

Orthis Saha, Ana Raquel Melo de Farias, Alexandre Pelletier…·Marcos R. Costa

This study shows BIN1 regulates L-type calcium channels in neurons, affecting calcium homeostasis and electrical activity, and links these changes to Alzheimer's disease pathology.

DOI 10.1101/2022.01.18.476601

𝕏 PostBluesky

NeuroscienceActa Neuropathologica CommunicationsPeer-reviewedJan 8, 2022

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects

Erwan Lambert, Orthis Saha, Bruna Soares Landeira…·Pierre Dourlen

This study shows that BIN1 isoform1 causes early endosome defects and neurodegeneration in Drosophila and human neurons, linking it to Alzheimer's disease pathology.

65 citationstop 1%

Drosophilaproteomics

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NeuroscienceFrontiers in Cellular NeurosciencePeer-reviewedNov 12, 2018

Evidence of Muller glia conversion into retina ganglion cells using Neurogenin2

Roberta Pereira de Melo Guimarães, Bruna Soares Landeira, Diego Marques Coelho…·Marcos R. Costa

This study shows that Neurogenin2 can reprogram Muller glia into retinal ganglion cell-like neurons, with efficiency comparable to ASCL1 but with distinct gene expression outcomes.

39 citations

mousebulk RNA-seq

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