Author

Xavier Hermant

Inserm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:Drosophila· 2 Approach:experimental assay· 2 Assay:electronic health records· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Erwan LambertiD· 2 shared Frank LafontiD· 2 shared Jean‐Charles LambertiD· 2 shared Nicolas BaroisiD· 2 shared Patrik VerstrekeniD· 2 shared Philippe AmouyeliD· 2 shared Pierre DourleniD· 2 shared Alejandra Freire‐RegatilloiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

Erwan LambertORCID

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2 papers

Recent·Most cited

BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicity

Erwan Lambert, Carla Gelle, Valentin Leclerc, Alejandra Freire‐Regatillo, Nicolas Barois, Tommy Malfoi, Xavier Hermant, Florie Demiautte, Frank Lafont, Philippe Amouyel, K. Blary, Sabine Kuenen, Chloé Najdek, Patrik Verstreken, Dolores Siedlecki‐Wullich, , Pierre Dourlen

This study shows that BIN1 isoform 1 expression in the presynaptic compartment causes synaptotoxicity, leading to synaptic loss and structural changes in Drosophila and rat models.

bioRxiv · Aug 11, 2025 · PreprintNeuroscience

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects

Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, , Pierre Dourlen

This study shows that BIN1 isoform1 causes early endosome defects and neurodegeneration in Drosophila and human neurons, linking it to Alzheimer's disease pathology.

Acta Neuropathologica Communications · Jan 8, 2022Peer-reviewedNeuroscience