Nicholas O. Markham

The paper creates a spatial atlas of early-stage colorectal cancer tumors to identify bacterial niches and their impact on tumor transcriptomes, highlighting C. difficile's significant influence despite low abundance.

This study shows aging restricts colorectal tumor growth by epigenetically silencing developmental gene programs, with implications for early-onset colorectal cancer.

The paper identifies a targeted cell lysis mechanism driven by TcdE that facilitates toxin release in Clostridioides difficile, revealing it as a bet-hedging strategy.

The paper uses clonal analysis to reveal species-specific differences in intestinal regeneration and stem cell dynamics in mice and humans.

The paper identifies a pathobiont-epithelial IDO1 pathway that drives region-specific susceptibility to inflammatory bowel disease in the ascending colon.

This study investigates whether inhibiting EGFR/ErbB receptors protects against C. difficile toxin B, finding no protective effect.

This study maps tumor evolution and microenvironment dynamics in colorectal cancer using spatial multi-omic data, identifying key genes associated with immune exclusion and prognosis.