Jenny M. Brown

A single dorsal vagal complex circuit mediates the aversive and anorectic responses to GLP1R agonists

This study identifies a single dorsal vagal complex circuit that mediates both aversive and anorectic responses to GLP1R agonists, showing that APGlp1r neurons are responsible for both effects.

A uniquely leptin sensitive hypothalamic neuron population limits hyperphagia and weight gain in diet-induced obesity

Molecularly defined subpopulations of leptin receptor neurons dissociate the control of food intake from blood pressure

The paper identifies distinct subpopulations of LeprGlp1r neurons that separately control food intake and blood pressure.

A Cross-Species Atlas of the Dorsal Vagal Complex Reveals Neural Mediators of Cagrilintide's Effects on Energy Balance

The paper creates a cross-species atlas of the dorsal vagal complex using single-nucleus RNA sequencing and spatial profiling, revealing molecular mechanisms of cagrilintide's effects on energy balance.

Role of hypothalamic MAPK/ERK signaling in diabetes remission induced by the central action of fibroblast growth factor 1

This study shows that sustained hypothalamic MAPK/ERK signaling is essential for FGF1-induced diabetes remission in rodents.