Abigail J. Tomlinson

A single dorsal vagal complex circuit mediates the aversive and anorectic responses to GLP1R agonists

This study identifies a single dorsal vagal complex circuit that mediates both aversive and anorectic responses to GLP1R agonists, showing that APGlp1r neurons are responsible for both effects.

A uniquely leptin sensitive hypothalamic neuron population limits hyperphagia and weight gain in diet-induced obesity

Molecularly defined subpopulations of leptin receptor neurons dissociate the control of food intake from blood pressure

The paper identifies distinct subpopulations of LeprGlp1r neurons that separately control food intake and blood pressure.

A unified rodent atlas reveals the cellular complexity and evolutionary divergence of the dorsal vagal complex

The paper creates a multi-species DVC cell atlas using snRNAseq, identifying cell types and novel populations in mouse and rat.

Control of Physiologic Glucose Homeostasis via the Hypothalamic Modulation of Gluconeogenic Substrate Availability

The paper identifies VMNCckbr neurons that regulate fasting blood glucose by enhancing adipose tissue lipolysis and substrate release via the sympathetic nervous system.

Neuronal SEL1L-HRD1 ERAD regulates one-carbon metabolism and is essential for motor function and survival

This study shows that neuronal SEL1L-HRD1 ERAD is critical for one-carbon metabolism, motor function, and survival, with loss leading to severe neurological defects.

A Cross-Species Atlas of the Dorsal Vagal Complex Reveals Neural Mediators of Cagrilintide's Effects on Energy Balance

The paper creates a cross-species atlas of the dorsal vagal complex using single-nucleus RNA sequencing and spatial profiling, revealing molecular mechanisms of cagrilintide's effects on energy balance.

Leptin-mediated suppression of food intake by conserved Glp1r-expressing neurons prevents obesity

The paper identifies a conserved population of GABAergic Glp1r-expressing LepRb neurons that mediate leptin's suppression of food intake and prevention of obesity.

Cross-Species Analysis Defines the Conservation of Anatomically-Segregated VMH Neuron Populations

The paper identifies conserved VMH neuron populations across species using TRAP-seq and snRNA-seq data, defining six major neuron classes with distinct anatomical and genetic features.